The study investigates the role of the derlin Dfm1 in the retrotranslocation and degradation of proteins with folded domains in the endoplasmic reticulum (ER). Using a model substrate, the research demonstrates that the Cdc48 ATPase activity is crucial for substrate retrotranslocation, independent of ERAD membrane components. However, complete degradation requires the coupling of retrotranslocation and proteasomal degradation, facilitated by Dfm1. Mutations in Dfm1 lead to partial degradation and accumulation of the folded domain, highlighting Dfm1's critical regulatory role in coordinating substrate retrotranslocation and degradation during ER-associated degradation (ERAD).

The article expresses skepticism about the integration of AI in future iPhone models, arguing that current AI capabilities available through apps like ChatGPT and Copilot are sufficient. It questions the practical benefits of AI integration in iOS 18, especially for users in Portugal, and suggests that significant improvements are unlikely.

Apple has confirmed the renewal of the successful series For All Mankind for a new season and announced a new spinoff series, Star City. Star City, produced by the same team, will focus on the space race from the Soviet Union's perspective, offering a unique narrative. Both series will be available on Apple TV+, enhancing the platform's appeal.

The article discusses the dual narratives surrounding the food industry and societal pressures on weight, focusing on the role of the food industry in promoting unhealthy eating habits. It highlights the prevalence of addiction to ultra-processed foods and the industry's tactics to make these foods appealing. The text argues for political intervention to regulate the market, citing the success of Portugal's sugar tax in reducing consumption and pressuring the industry to offer healthier options. It calls for broader policies, such as additional taxes on unhealthy foods and restrictions on their sale in certain areas, to protect vulnerable populations. The article also emphasizes consumer responsibility in making healthier choices.

A Suzhou Yidaibao Intelligent Technology, uma empresa chinesa, desenvolveu uma jaqueta inflável que funciona como um airbag para prevenir ferimentos graves em caso de quedas. O produto, que começou a ser vendido recentemente, utiliza um micro giroscópio e um processador para detectar quedas e inflar em apenas 0,18 segundos. A China é destacada como líder na revolução tecnológica atual, com inovações em diversos setores. O mercado para este produto é vasto, com uma população idosa significativa na China e no mundo, que está projetada para crescer ainda mais nas próximas décadas.

O artigo discute um vídeo viral de uma garçonete chinesa que finge ser um robô humanoide, destacando a habilidade da dançarina profissional em simular movimentos robóticos. O South China Morning Post confirmou que era uma pessoa e não um robô. O texto aborda o plano da China de se tornar líder mundial em robótica até 2025, com aplicações em saúde, serviços domésticos, agricultura, logística e situações perigosas. O artigo também menciona a presença de garçons robôs ao redor do mundo, incluindo 5 mil na Coreia e exemplos nos EUA e Brasil, onde robôs servem clientes em restaurantes e quiosques, destacando o avanço da robótica global.

Um projeto de lei no Uruguai, chamado Rendición de Cuentas, que trata dos direitos autorais de música, está causando a saída do Spotify do país. A lei exige que plataformas de streaming paguem de forma 'justa e equitativa' aos artistas, incluindo compensação por reproduções em redes sociais. O Spotify argumenta que já paga 70% de suas receitas de música para gravadoras e editoras e que custos adicionais tornariam o negócio insustentável. Apesar de não ter sido regulamentado pelo presidente Luis Lacalle Pou, a aprovação parlamentar foi suficiente para a decisão da empresa sueca de encerrar suas operações no Uruguai em 2024. O país se juntará a uma lista de nações onde o Spotify não está disponível.

Lorena Louisy is a Brazilian internet and TV celebrity known for her appearances on Record TV's 'A Fazenda' and 'Power Couple Brasil'. Following her TV career, she launched her own news website, Lorena.R7, aiming to provide a comprehensive and respectful news source without sensationalism, covering a variety of topics. The site is known for not distorting celebrity statements and has featured interviews with famous personalities such as Bruna Marquezine and Roberto Justus. The editorial team consists of a chief editor, six editors, and sixty journalists and journalism students, covering topics like fashion, celebrities, cinema, awards, reality shows, health and wellness, TV, and beauty.

The Brazilian artist Anitta has made it onto the Billboard Hot 100 for the third time with her song 'BELLAKEO', featuring Mexican rapper Peso Pluma, debuting at #71. Her previous tracks 'Envolver' and 'Me Gusta', which included artists Cardi B and Mykee Towers, also charted in the past. 'BELLAKEO' is also performing well on streaming platforms, ranking 22nd on Spotify's 'Top 50 - World' and 8th on YouTube Music's weekly list. Anitta is preparing for her next album 'Funk Generation', set to release in the first half of 2024, which will feature classic and alternative funk tracks, including samples from DJs like Malboro and Dennis. She won her second consecutive VMA for 'Best Latin Music Video' with 'Funk Rave'. Anitta is also planning pre-Carnival shows across various Brazilian cities.

A new documentary miniseries titled 'Se Eu Fosse Luísa Sonza' has been released on Netflix, featuring the career of 25-year-old Brazilian pop artist Luísa Sonza. The three-episode series follows Sonza from late 2022, offering an intimate look into her life and career up to the release of her latest album, 'Escândalo Íntimo'. The documentary covers her personal and professional life, including her relationships, particularly with comedian Whindersson Nunes, and touches on her challenges, such as a racism incident in 2018 and her psychological crises, including panic attacks and professional burnout. The series also showcases her musical talent and resilience, with filming locations ranging from her hometown in Rio Grande do Sul to Los Angeles.