The article discusses the impact of humanitarian disasters, particularly pandemics like COVID-19 and the Spanish Flu, on economies and businesses. It contrasts economic depressions with disasters, highlighting that human behavior drives economic outcomes in the latter. The piece reflects on the Spanish Flu's origins and its economic effects, including businesses that thrived and new opportunities that arose. It cites research suggesting that non-pharmaceutical interventions (NPIs) can help maintain economic activity during pandemics. The article also explores potential new business ventures in the context of COVID-19, such as mental health services and micro-insurance for the poor. It concludes by encouraging a mindset shift to view challenges as opportunities for personal growth and societal contribution.